2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125787
    MLS000389544
    		Antagonist
    MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
    MLS000389544
  • HY-W010696AS
    Reverse T3-13C6 hydrochloride
    Reverse T3-13C6 (hydrochloride) is the 13C labeled Reverse T3[1].
    Reverse T3-<sup>13</sup>C<sub>6</sub> hydrochloride
  • HY-153637
    THR-β modulator-1
    		Modulator
    THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders.
    THR-β modulator-1
  • HY-P4696
    pTH (3-34) (bovine)
    pTH (3-34) (bovine) is apTH ((Human parathyroid hormone) fragment.
    pTH (3-34) (bovine)
  • HY-18341S4
    L-Thyroxine-13C6-1
    L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine-<sup>13</sup>C<sub>6</sub>-1
  • HY-B1201R
    Tiratricol (Standard)
    Tiratricol (Standard) is the analytical standard of Tiratricol. This product is intended for research and analytical applications. Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication..
    Tiratricol (Standard)
  • HY-B0596S
    Taltirelin-13C,d3
    		Agonist
    Taltirelin-13C,d3 (TA-0910-13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
    Taltirelin-<sup>13</sup>C,d<sub>3</sub>
  • HY-116325
    3,5,3'-Triiodo-D-thyronine
    		Activator
    3,5,3'-Triiodo-D-thyronine, a thyroid hormone, is less effective than 3,5,3'-Triiodo-T-thyronine in normalizing the increased plasma creatine phosphokinase (CPK) activity.
    3,5,3'-Triiodo-D-thyronine
  • HY-133846
    Iodothiouracil
    Iodothiouracil exhibits high selectivity for melanoma, remains stable in the melanin in melanoma cells, and localizes remote secondary metastases of melanoma. Iodothiouracil can be used for melanoma imaging when labeled with iodine-123, and can be used for radiation therapy when labeled with iodine-131.
    Iodothiouracil
  • HY-P4817
    Human PTH-(1-31)
    Human PTH-(1-31) is the 1-31 fragment of human PTH. Human PTH-(1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) induces bone formation without inducing bone resorption. Human PTH-(1-31) has the potential for the research of osteoporosis.
    Human PTH-(1-31)
  • HY-12753AR
    Debutyldronedarone (hydrochloride) (Standard)
    		Inhibitor
    Debutyldronedarone (hydrochloride) (Standard) is the analytical standard of Debutyldronedarone (hydrochloride). This product is intended for research and analytical applications. Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone (hydrochloride) (Standard)
  • HY-120358
    L-6424
    		Inhibitor
    L-6424 inhibits T3 binding to α1-T3R and β1-T3R.
    L-6424
  • HY-119858
    Acetiromate
    Acetiromate is a thyroxine analogue. Acetiromate is an antilipidemic drug for hyperlipidemia.
    Acetiromate
  • HY-P4800
    Osteostatin (human)
    		Modulator
    Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis.
    Osteostatin (human)
  • HY-117178
    TA 0910 acid-type
    		Control 99.85%
    TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH).
    TA 0910 acid-type
  • HY-118978
    PF-00277343
    		Agonist
    PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models.
    PF-00277343
  • HY-A0152A
    D-Thyroxine sodium
    		Inhibitor
    D-thyroxine (D-T4) sodium is an orally active thyroid hormone that inhibits the secretion of TSH. D-thyroxine sodium can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-thyroxine sodium can be used for the study of hypercholesterolemia.
    D-Thyroxine sodium
  • HY-153477
    Thyroid hormone receptor beta agonist-1
    		Agonist
    Thyroid hormone receptor beta agonist-1 (compound 3) is a thyroid beta-agonist.
    Thyroid hormone receptor beta agonist-1
  • HY-142917
    THR-β agonist 4
    		Agonist
    THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72).
    THR-β agonist 4
  • HY-116701
    A 274
    		Inhibitor
    A 274 is an amiodarone analogue that has the activity of inhibiting the binding of T3 to α1- and β1-thyroid hormone receptors in vitro. Its IC50 values for inhibition of α1-T3R and β1-T3R are certain values (depending on the specific experimental results).
    A 274
Cat. No. Product Name / Synonyms Application Reactivity